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The shielding problem can be mitigated (partially) by distance. Unshielded dose follows the inverse square law. The USS Discovery in 2001: A Space Odyssey captured that quite accurately. The propulsion section was seperated from the habitation section by a long pylon. Waste heat radiators are a more difficult problem. One way of making them smaller is to dump heat at higher temperatures. The heat flux from a radiator scales with the fourth power of temperature. But that causes problems as well if the heat produced by a reactor is needed to run some sort of heat engine. Dumping heat at higher temperature then negatively impacts efficiency.
I cannot really comment on your 10B-P fusion engine design.
"Plan and prepare for every possibility, and you will never act. It is nobler to have courage as we stumble into half the things we fear than to analyse every possible obstacle and begin nothing. Great things are achieved by embracing great dangers."
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